Table 1. General-Purpose Metabolic Databases
 
Database Name
Contents
Support of
Comments and References
Comparative Analysis of Metabolic Pathways
Automated Metabolic Reconstruction
Library of "Signature Enzymes" 
The Boehringer Mannheim Biochemical Pathways (SwissProt) A collection of metabolic pathways integrated into the Swiss Protein Data Bank connected to data about enzymes, and sequence data.
 
No
No
No
[3], [4], [5]
KEGG  

(Kyoto University, Japan)  
 

 A collection of overview pathway diagrams, representing some alternative pathways. Connected to the sequence data and ligand database of enzymes.
Concentrates on representation of metabolic network rather then the processes.
No
Yes
No
[6], [7]
EcoCyc A detailed encoding of the metabolism of Escherichia coli and Haemophilus influenzae. Includes, besides the metabolic network, some of the kinetic and thermodynamic parameters when they are known. 
No
No
No
[8], [9]
MetaCyc Contains pathway diagrams connected to sequence data. Linked to WIT system [17]. Represents initial stages of its development.
No
No
No
[10]
The Biocatalysis Biodegradation Database Covers a small, but significant, set of pathways that are of special interest in the area of xenobiotic degradation. 
No
No
No
[11]
SoyBase A collection of the metabolic pathways relevant to legumes. Connected to the enzymatic and sequence data information
No
No
No
[12]
The Maize DB Maintains a comprehensive collection of what is known of the maize genetic and biochemistry.
[13]
Proposed PUMA2 Based on collection of metabolic modules, derived from the EMP/MPW collection of metabolic pathways, other metabolic databases, and literature information. 
Yes
Yes
Yes